The same year he was cast in Michael Bay's science fiction film Transformers as Sam Witwicky, the main protagonist of the series.
Transformers was a box office success and one of the highest-grossing films of 2007.
In April 2012, he promoted them at Chicago Comic & Entertainment Expo.
In June 2012, the Icelandic band Sigur Rós released a video for the song "Fjögur Píanó", starring La Beouf, in which he appears nude.
His next film was Eagle Eye, released on September 26.
His performance received mixed reviews, with Josh Bell of Las Vegas Weekly saying he "makes a credible bid for action-hero status, although his occasional stabs at emotional depth don't really go anywhere." In February, La Beouf made his music video directorial debut, directing the video for "I Never Knew You", a single by American rapper Cage, from his third album Depart from Me (2009).
His first name is derived from Szaja, the Polish version of the Hebrew Yeshayahu (Isaiah), meaning "God is salvation." La Beouf has described his parents as "hippies", his father as "tough as nails and a different breed of man", and his upbringing as similar to a "hippy lifestyle", stating that his parents were "pretty weird people, but they loved me and I loved them." film adaptation Holes (2003).
In 2005, he co-starred in Constantine, playing the role of Chas Kramer, with Keanu Reeves in the starring role.
He made his film debut in The Christmas Path (1998).In 2012, Rob Cantor of Tally Hall produced a song describing La Beouf as a murderous cannibal.In 2014, Cantor produced a music video based on this song.The same year he provided the voice of Asbel in the Disney-produced English dub of Nausicaä of the Valley of the Wind.La Beouf made his directorial debut with the short film Let's Love Hate with Lorenzo Eduardo.